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Combination drug strategy produces promising results by hyperactivating oncogenic signaling

A combination of two drugs was capable of suppressing tumors in a non-conventional manner. Instead of inhibiting tumor cell division, as the most widely used medications do, the strategy consisted of hyperactivating oncogenic ...

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Chinese medicinal fungus shows promise in treating idiopathic pulmonary fibrosis

A study from China has reported that Cordyceps sinensis (CS), a traditional Chinese medicinal fungus, can ameliorate idiopathic pulmonary fibrosis (IPF) in mice by inhibiting mitochondrion-mediated oxidative stress.

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Self-amplifying mRNA vaccines appear safe in lab and animal tests

mRNA vaccines contain instruction codes for making parts of pathogenic viruses. Can so-called self-amplifying types of such vaccines form unwanted and dangerous connections with other viruses? Yes, say Wageningen virologists ...

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How a bacterium supports healing of chronic diabetic wounds

There are many important reasons for keeping cuts and sores clean, but new research from the Perelman School of Medicine at the University of Pennsylvania shows that a certain bacterium, Alcaligenes faecalis (A. faecalis), ...

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Study debunks link between moderate drinking and longer life

Probably everyone has heard the conventional wisdom that a glass of wine a day is good for you—or you've heard some variation of it. The problem is that it's based on flawed scientific research, according to a new report ...

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New protein discovery may influence future cancer treatment

Researchers from the University of Otago, Christchurch, have spearheaded the discovery of a protein function which has the potential to guide the development of novel cancer treatment options and improve the diagnosis of ...

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Guideline on management of central airway obstruction released

The American College of Chest Physicians (CHEST) recently released a new clinical guideline on central airway obstruction (CAO). Published in the journal CHEST, the guideline contains 12 evidence-based recommendations to ...

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Issues with fracture healing in people with Down syndrome

New research from the Texas A&M School of Veterinary Medicine & Biomedical Sciences (VMBS) is the first to provide direct experimental evidence that people with Down syndrome may not heal from bone fractures.

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Scientists identify pathway to curb spread of brain cancer

UT Southwestern researchers have identified a molecular pathway responsible for the spread of glioblastoma to surrounding tissue in the brain, as well as an existing drug that curbed tumor growth in animal models. The findings, ...

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Collagen a key player in breast cancer metastasis

Collagen type XII plays a key role in regulating the organization of the tumor matrix, reveals a new study from the Garvan Institute of Medical Research. A team of scientists led by Associate Professor Thomas Cox, Head of ...

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New target identified for treatment of premature aging disease

A stretch of DNA that hops around the human genome plays a role in premature aging disorders, scientists at the Salk Institute and King Abdullah University of Science and Technology (KAUST) in Saudi Arabia have discovered. ...

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Multiple sclerosis drug works in a surprising way

Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce ...

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FDA takes steps away from animal testing requirement

In response to increasing pressure, the U.S. Food and Drug Administration (FDA) is re-examining its requirement for animal tests to be performed for products under its jurisdiction. A story in Chemical & Engineering News, ...

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Body posture affects how oral drugs absorbed by stomach

A common, economic, and easy method of administering drugs is orally, by swallowing a pill or capsule. But oral administration is the most complex way for the human body to absorb an active pharmaceutical ingredient, because ...

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Circadian clocks play a key role in fat cell growth

Disruption of the circadian clocks that keep the body and its cells entrained to the 24-hour day-night cycle plays a critical role in weight gain, according to a pair of studies by Weill Cornell Medicine investigators.