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Investigational mpox mRNA vaccine more effectively reduces disease severity in primates compared to available vaccines

The most frequently used mpox vaccine provides partial immunity to the disease but isn't always able to prevent severe symptoms or disease transmission. A new vaccine candidate from Moderna, mRNA-1769, more effectively limits ...

Medical research

Newly discovered gene may influence longevity in humans

Sleep, fasting, exercise, green porridge, black coffee, a healthy social life—there is an abundance of advice out there on how to live a good, long life. Researchers are working hard to determine why some people live longer ...

Medical research

New approach moves cell therapy closer to treating many disorders

A new approach to manufacturing cells that secrete and deliver therapies to specific parts of the body has taken a big step toward one day repairing joints and damage after heart attacks, countering transplant rejection and ...

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Blood stem cell research could transform bone marrow transplants

Melbourne researchers have made a world first breakthrough in creating blood stem cells that closely resemble those in the human body. And the discovery could soon lead to personalized treatments for children with leukemia ...

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Ultrasound device shows promise for treating chronic pain

Pain is a necessary biological signal, but a variety of conditions can cause those signals to go awry. For people with chronic pain, the root is often faulty signals emerging deep within the brain, giving false alarms about ...

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Review highlights advances in kidney cancer research and care

New insights into the biology of kidney cancer, including those informed by scientific discoveries that earned a Nobel Prize, have led to advances in treatment and increased survival rates, according to a review by UNC Lineberger ...

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Ozone exposure link to the development of type 2 diabetes

Older Californians who live in communities with poor air quality, even those who engage—as recommended—in physical activities but do so outdoors, have a higher risk of Type 2 diabetes, a complex and chronic metabolic ...

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Drug repurposing is no panacea in race to treat COVID-19

Drug repurposing is no quick fix for developing new treatments for disease, including COVID-19, and there are inherent dangers and pitfalls with translating drugs such as chloroquine, hydroxychloroquine, ivermectin and ...

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Are too many Phase III cancer clinical trials set up to fail?

New research in the September 2021 issue of JNCCN—Journal of the National Comprehensive Cancer Network finds that more than 80% of therapies tested in Phase III oncology trials did not achieve meaningful clinical benefit ...

Medical research

Eating less fat may save your hair

It's well known that obesity is linked to the development of numerous diseases in humans. Heart disease, diabetes, and other ailments are extremely common in obese individuals. However, it's not fully clear how body organs ...

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Researchers build embryo-like structures from human stem cells

Research on human embryos is vital to understanding the earliest stages of human development. Currently, this research is conducted on surplus embryos willingly donated by individuals who have undergone in vitro fertilization. ...

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Studying aging through metabolite changes in saliva

Researchers in Japan have conducted a comprehensive analysis of the metabolites that make up human saliva using samples given voluntarily from a group of 27-to-33-year-old individuals and a group of 72-to-80-year-old individuals. ...

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Can fruit fly research help improve survival of cancer patients?

The experience of a fruit fly dying from cancer may seem worlds away from that of a human with a life-threatening tumor, yet University of California Berkeley researchers are finding commonalities between the two that could ...

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Blueprint for regulating lab-developed diagnostic tests

How should diagnostic tests developed in laboratories in hospitals and other health care settings be regulated—if at all? That's a question that has stirred lively debate within the U.S. health care system for years, but ...

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Building the ovarian environment from stem cells

Researchers led by Kyushu University have succeeded in using mouse stem cells to reconstruct structures in the ovarian environment critical for the generation of mature egg cells. Moreover, they were able to apply their findings ...