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Self-amplifying mRNA vaccines appear safe in lab and animal tests

mRNA vaccines contain instruction codes for making parts of pathogenic viruses. Can so-called self-amplifying types of such vaccines form unwanted and dangerous connections with other viruses? Yes, say Wageningen virologists ...

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How a bacterium supports healing of chronic diabetic wounds

There are many important reasons for keeping cuts and sores clean, but new research from the Perelman School of Medicine at the University of Pennsylvania shows that a certain bacterium, Alcaligenes faecalis (A. faecalis), ...

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New protein discovery may influence future cancer treatment

Researchers from the University of Otago, Christchurch, have spearheaded the discovery of a protein function which has the potential to guide the development of novel cancer treatment options and improve the diagnosis of ...

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Study debunks link between moderate drinking and longer life

Probably everyone has heard the conventional wisdom that a glass of wine a day is good for you—or you've heard some variation of it. The problem is that it's based on flawed scientific research, according to a new report ...

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Guideline on management of central airway obstruction released

The American College of Chest Physicians (CHEST) recently released a new clinical guideline on central airway obstruction (CAO). Published in the journal CHEST, the guideline contains 12 evidence-based recommendations to ...

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Cure for male pattern baldness given boost by sugar discovery

The key to curing male pattern baldness—a condition that affects up to 50% of men worldwide—could lie in a sugar that naturally occurs in the human body, according to scientists at the University of Sheffield.

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Peptide cocktails show promise in combating antibiotic resistance

Antibiotics are essential tools in modern medicine, regularly used to treat bacterial infections and prevent infections during surgery. However, the widespread use of antibiotics has led to many bacteria developing resistance, ...

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Psychedelic drugs: How to tell good research from bad

Research with psychedelic drugs has made a dramatic comeback amid a heady mix of softening societal attitudes, the lure of commercial opportunity, misgivings about the "war on drugs," and the desire to develop new ways to ...

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Team develops behavioral test to detect early risk of Alzheimer's

Alzheimer's disease is a neurodegenerative condition that damages a person's ability to think, remember, and perform basic functions. According to the National Institutes of Health, Alzheimer's affects more than 6 million ...

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Breakthrough brings potential glioblastoma drug into focus

Glioblastoma, the most common cancerous brain tumor in adults, is an aggressive disease—patients survive an average of just 15 months once they are diagnosed. Despite more than two decades of research on the causes and ...

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This molecule could be behind liver fibrosis

The liver is the all-important organ behind processing of various substances we put into our bodies, from food and drink to alcohol and drugs. When things go awry with the liver, the consequences can be deadly. At the root ...

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Disarming the immune system's lethal lung response

Neutrophils, the most abundant type of white blood cell, are the body's first line of defense against infection. Foreign pathogens can stress the body and activate neutrophils. When activated, neutrophils employ various weapons ...

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Shape-shifting fat cells fuel breast cancer growth

Fat cells, or adipocytes, that grow in close proximity to breast cancers can shift into other cell types that promote tumor growth, a new study by UT Southwestern researchers suggests. The findings, published in Cell Reports, ...

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Online atlas shows strong link between gut bacteria and metabolites

There are strong links between bacteria living in the gut and the levels of small molecules in the blood known as metabolites. This is the finding of a new study led by researchers from Uppsala University and Lund University, ...

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How the small intestine defends itself against bacteria

Researchers at the University of Gothenburg have been studying the mucus involved in defending the intestines and airways against infection for more than 30 years. To date, their work has focused very much on the large intestine, ...

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Heat stress prompts kidneys to tap into their reserves

Acute kidney injury—defined as an abrupt decline in glomerular filtration rate (GFR)—is among the top causes of hospitalization during a heat wave. New research published ahead of print in the American Journal of Physiology-Regulatory, ...

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Experimental brain cancer drug fast tracked in clinical trials

An experimental drug being trialed for advanced solid tumors, including the most aggressive brain cancer—glioblastoma—has passed the first phase with flying colors, raising hopes for an effective new treatment.

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What is a Hispanic biobank?

A growing number of people in the U.S. identify as Hispanic. That has the medical community looking closer at diversifying information and samples that can apply to a broader patient population.

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Awakening dormant cells to fight cancer

The advent of small-molecule targeted therapies, a decade ago, revolutionized the treatment of metastatic melanoma, provided that the tumors carry the mutations to respond to these treatments. However, despite a remarkable ...

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Could monoclonal antibodies replace opioids for chronic pain?

During the pandemic, physicians used infusions of monoclonal antibodies—antibodies made in a lab—to help patients fight off COVID-19 infections. Now, researchers at UC Davis are trying to create monoclonal antibodies ...

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Researchers turn cancer cells into less harmful cell types

Cancer occurs when cells grow uncontrollably and spread to other organs in the body. Cancer cells differ from normal cells in many ways. One characteristic of cancer cells is their high adaptability to different environments ...