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Immunology news
Oncology & Cancer
Harnessing natural killer T cells to advance cancer immunotherapy for solid tumors
In the fight against cancer, chimeric antigen receptor T cell (CAR-T) therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors.
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Oncology & Cancer
Epigenetic test could help predict efficacy of immunotherapy in multiple myeloma
Multiple myeloma is a type of blood cancer that appears mainly after the age of 60. Its incidence, therefore, increases with the aging of the population. In this pathology, the bone marrow, the porous structure within the ...
2 hours ago
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New immunotherapy shows complete responses in mantle cell lymphoma
Patients with a rare blood cancer that has relapsed or become resistant to treatment have shown a high response rate to a potent new immunotherapy drug, in a Peter Mac-led clinical trial.
2 hours ago
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Long COVID patients with abnormal lung CT scans could prove key to preventing pulmonary fibrosis
Long COVID occurs in approximately a third of COVID-19 survivors, with the CDC estimating one in 13 adults in the United States have long COVID symptoms such as brain fog, shortness of breath and chest pain. In a new study ...
4 hours ago
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Scientists discover that special immune cells stop metastatic cancer
Metastatic disease—when cancer spreads from the primary tumor to other parts of the body—is the cause of most cancer deaths. While researchers understand how cancer cells escape the primary site to seed new tumors, it's ...
5 hours ago
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Promising cell therapy offers hope for relapsed or refractory T-cell leukemia
A new cell therapy, targeting CD7 in leukemia cells, gives a potentially effective treatment for patients with T-cell acute lymphoblastic leukemia (T-ALL) who have exhausted all standard treatment options. Published in the ...
5 hours ago
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Gut bacteria engineered to act as tumor GPS for immunotherapies
Immunotherapeutic approaches have substantially improved the treatment of patients with advanced malignancies. However, most advanced and metastatic malignancies remain incurable and therefore represent a major unmet need.
Oct 4, 2024
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Study unveils the role of gamma-delta T cells in cancer immunology
A new study published in Cell Reports Medicine reveals critical insights into the role of gamma-delta T cells across 33 cancer types, shedding light on their potential as clinical biomarkers and therapeutic targets in cancer ...
Oct 4, 2024
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Cilta-cel found highly effective in first real-world study of patients with relapsed or refractory multiple myeloma
In the first study to report real-world outcomes from ciltacabtagene autoleucel (cilta-cel), a chimeric antigen receptor (CAR)-T therapy for multiple myeloma, patients experienced efficacy and safety results similar to those ...
Oct 4, 2024
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Research reveals gene expression's role in depression and immunity
A new study, conducted in a shared effort between U.K. and Italian researchers offers novel insights about the biological mechanisms behind major depressive disorder (MDD), and especially on the role of the immune system.
Oct 4, 2024
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Experimental blood test improves early detection of pancreatic cancer
An experimental blood test detects early-stage pancreatic cancer more effectively than other available tests, reports a new study published in Cancer Letters. The findings pave the way for further evaluation of the test in ...
Oct 4, 2024
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Biomarker can help health care assess severity of COVID-19
Researchers at Karolinska Institutet and the University of Gothenburg have identified a biomarker that could become an important tool for health care in assessing patients with acute COVID-19 infection. The researchers have ...
Oct 4, 2024
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Understanding liver fibrosis: Insights from Alagille syndrome
What influences the extent of scar tissue, or fibrosis, that develops in the liver when people suffer from liver disease? While a small amount of fibrosis is a normal part of the healing process, excessive fibrosis can occur, ...
Oct 4, 2024
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Here's why B cells benefit from booster shots
Certain infectious diseases, such as COVID or the flu, evolve constantly, shapeshifting just enough to outmaneuver our immune systems and reinfect us repeatedly. But subsequent reinfections often don't lead to the most severe ...
Oct 3, 2024
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Scientists discover new mechanism controlling T-cells in inflammation
Northwestern Medicine scientists have discovered a new mechanism that controls a specialized group of T-cells, known as regulatory T-cells, and may serve as potential therapeutic targets to treat inflammatory disorders and ...
Oct 3, 2024
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Viruses found hiding in lungs' immune cells long after initial illness
Doctors have long known that children who become seriously ill with certain respiratory viruses such as respiratory syncytial virus (RSV) are at elevated risk of developing asthma later in life. What they haven't known is ...
Oct 2, 2024
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Curbing blood cancers by teaching immune cells to kill mutant stem cells
Blood stem cells, which give rise to all of our blood cell types, undergo a quality assurance process after they're born. As the lab of Leonard Zon, MD, director of the Stem Cell Research program at Boston Children's, has ...
Oct 2, 2024
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Scientists uncover genetic cause of rare autoimmune disorder
A team of international scientists has uncovered the genetic underpinnings of a rare, inherited autoimmune disorder, according to a study recently published in Science Translational Medicine.
Oct 2, 2024
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New cardiovascular disease risk marker discovered in older women
Researchers at Karolinska Institutet have identified a new potential risk marker for cardiovascular disease in women. A new study shows an association between low levels of an anti-inflammatory antibody and the risk of heart ...
Oct 2, 2024
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Combining cell therapy with approved drug shows promise for treating multiple sclerosis
Multiple sclerosis (MS) is a long-term disease where the immune system mistakenly attacks the protective layer around nerve cells, known as the myelin sheath. This leads to nerve damage and worsening disability. Current treatments, ...
Oct 2, 2024
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Researchers propose a new treatment for brain metastasis based on immunotherapy
Researchers at the Spanish National Cancer Research Center (CNIO) propose a new treatment for brain metastases that respond poorly, or not at all, to immunotherapy, and provide a biomarker to predict in which cases it should ...
Oct 2, 2024
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Unveiling genetic insights: How PAI-1 polymorphisms influence COVID-19 outcomes
Despite global vaccination efforts, COVID-19 continues to pose significant risks, leading to severe complications and fatalities. These risks are driven by disrupted coagulation, impaired fibrinolysis, which is the process ...
Oct 2, 2024
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How to get hay fever relief from fall allergies
Autumn is the season of change, with green leaves turning color and temperatures cooling. It's also the season of hay fever, or allergic rhinitis.
Oct 2, 2024
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Researchers build first large-scale atlas of how immune cells react to mutations during cancer immunotherapy
A Cleveland Clinic-led research collaboration between Timothy Chan, MD, Ph.D., Chair of Cleveland Clinic's Global Center for Immunotherapy, and Bristol Myers Squibb has published the most comprehensive overview to date of ...
Oct 1, 2024
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New mouse models offer valuable window into COVID-19 infection
Scientists at La Jolla Institute for Immunology (LJI) have developed six lines of humanized mice that can serve as valuable models for studying human cases of COVID-19.
Oct 1, 2024
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