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Self-amplifying mRNA vaccines appear safe in lab and animal tests

mRNA vaccines contain instruction codes for making parts of pathogenic viruses. Can so-called self-amplifying types of such vaccines form unwanted and dangerous connections with other viruses? Yes, say Wageningen virologists ...

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How a bacterium supports healing of chronic diabetic wounds

There are many important reasons for keeping cuts and sores clean, but new research from the Perelman School of Medicine at the University of Pennsylvania shows that a certain bacterium, Alcaligenes faecalis (A. faecalis), ...

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New protein discovery may influence future cancer treatment

Researchers from the University of Otago, Christchurch, have spearheaded the discovery of a protein function which has the potential to guide the development of novel cancer treatment options and improve the diagnosis of ...

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Study debunks link between moderate drinking and longer life

Probably everyone has heard the conventional wisdom that a glass of wine a day is good for you—or you've heard some variation of it. The problem is that it's based on flawed scientific research, according to a new report ...

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Guideline on management of central airway obstruction released

The American College of Chest Physicians (CHEST) recently released a new clinical guideline on central airway obstruction (CAO). Published in the journal CHEST, the guideline contains 12 evidence-based recommendations to ...

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Cure for male pattern baldness given boost by sugar discovery

The key to curing male pattern baldness—a condition that affects up to 50% of men worldwide—could lie in a sugar that naturally occurs in the human body, according to scientists at the University of Sheffield.

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Peptide cocktails show promise in combating antibiotic resistance

Antibiotics are essential tools in modern medicine, regularly used to treat bacterial infections and prevent infections during surgery. However, the widespread use of antibiotics has led to many bacteria developing resistance, ...

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Project aims to achieve cell-based heart repair

Chronic heart failure—also known as cardiac insufficiency in medicine—is the most common reason for hospital admissions and one of the most frequent causes of death in the western world. In Germany alone, 4 million people ...

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Establishing a novel strategy to tackle Huntington's disease

Through an international joint research effort involving ProQR Therapeutics of the Netherlands, Université Grenoble Alpes of France, and KTH Royal Institute of Technology of Sweden, Professor Ji-Soon Song's research team ...

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Study shows an improved way to model type 2 diabetes in mice

Type 2 diabetes affects the lives of millions of Americans and is estimated to cost $327 billion in health care and productivity lost annually. It is also associated with pain, lower urinary tract or bladder dysfunction, ...

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Proxidrugs in the fight against pathogenic proteins

Cells have an efficient waste disposal system. Proxidrugs utilize this system as part of new treatments for cancer, infections and Alzheimer's disease. Scientists at the Fraunhofer Institute for Translational Medicine and ...

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Old drugs hint at new ways to beat chronic pain

Pain is an important alarm system that alerts us to tissue damage and prompts us to withdraw from harmful situations. Pain is expected to subside as injuries heal, but many patients experience persistent pain long after recovery. ...

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Scientists eavesdrop on communication between fat and brain

What did the fat say to the brain? For years, it was assumed that hormones passively floating through the blood were the way that a person's fat—called adipose tissue—could send information related to stress and metabolism ...

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Stressed mitochondria help cells survive respiratory infections

Many respiratory infections, such as influenza or COVID-19 add significant stress to cells and organs, which can lead to acute respiratory distress syndrome (ARDS), which itself can eventually cause death in aged or sensitive ...

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Whole-blood RNA profiling of severe COVID cases

Just as a recipe contains the instructions needed to make a dish, messenger ribonucleic acid (mRNA) sequences in the body contain the information needed to make proteins. Changes in the expression of specific mRNAs and short ...