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Immunology news
Oncology & Cancer
Pan-cancer analysis uncovers a new class of promising CAR T–cell immunotherapy targets
Targeting anti-cancer therapy to affect cancer cells but not healthy cells is challenging. For chimeric antigen receptor (CAR) T–cell immunotherapy, where a patient's own immune cells are re-engineered to attack cancer ...
May 3, 2024
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Oncology & Cancer
Newly discovered mechanism of T-cell control can interfere with cancer immunotherapies
Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system. In this way, the body presumably curbs destructive immune reactions.
23 hours ago
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Scientists discover new immunosuppressive mechanism in brain cancer
The Wistar Institute assistant professor Filippo Veglia, Ph.D., and team, have discovered a key mechanism of how glioblastoma—a serious and often fatal brain cancer—suppresses the immune system so that the tumor can grow ...
23 hours ago
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New approach for developing cancer vaccines could make immunotherapies more effective in acute myeloid leukemia
Acute myeloid leukemia (AML) is a type of blood cancer that forms in the soft marrow of the bones, typically attacking cells that would otherwise form the key component of the body's immunodefense system, white blood cells.
22 hours ago
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Drug targeting RNA modifications shows promise for treating neuroblastoma
Neuroblastoma is a common pediatric cancer that originates in developing nerve cells outside the brain. While increasingly intensive treatments have improved the survival of patients with high-risk neuroblastoma, currently ...
22 hours ago
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Lymphocytes recruit the immune system to fight most aggressive breast cancer, study confirms
Researchers at the UAB and the Hospital del Mar Research Institute have confirmed that patients with the presence of NK lymphocytes around tumors have a better response to treatment. This confirms the feasibility of using ...
May 3, 2024
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Researchers discover how immune B cells hunt down cancer around the body
Scientists have discovered the key features of immune B cells that make them successful at targeting tumors—including when cancer has spread to a different part of the body.
May 2, 2024
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Controlled human infection study paves the way to improving vaccines and therapeutics development
A first-of-its-kind study led by the University of Oxford has successfully investigated human immunity against COVID-19 in people who already have antibodies against it. The results suggest that previous infection, together ...
May 2, 2024
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Gene signatures from tissue-resident T cells as a predictive tool for melanoma patients
An extensive analytical study conducted at the Terasaki Institute for Biomedical Innovation (TIBI) has revealed an association between favorable survival outcomes for melanoma patients and the presence of higher populations ...
May 2, 2024
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Turning a tumor's 'shield' into a weapon against itself
Tumor cells are "cunning," according to Peter Yingxiao Wang. They have a nefarious way of evading the human immune responses that fight back against these cancerous invaders. Tumor cells express programmed death-ligand 1 ...
May 2, 2024
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Activation of innate immunity: Important piece of the puzzle identified
LMU researchers have deciphered the complex interplay of various enzymes around the innate immune receptor toll-like receptor 7 (TLR7), which plays an important role in defending our bodies against viruses.
May 2, 2024
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Study reveals hidden diversity of innate immune cells
Findings from a new study, led by researchers at Dartmouth's Geisel School of Medicine and published in Nature Immunology, have uncovered key functional differences in macrophages—a type of white blood cell that plays a ...
May 2, 2024
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Skin patch improves treatment for pediatric milk allergies
Daily immunotherapy delivered via a dermal patch reduced the risk of reactions, including anaphylaxis, in children with an immunoglobulin E (IgE)–mediated cow's milk allergy, according to a recent clinical trial published ...
May 2, 2024
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Molecular testing: Pioneering precision medicine for colorectal cancer
A new perspective paper explores the current state and future directions of precision medicine in colorectal cancer (CRC). It outlines advancements in molecular testing and their implications for targeted and immunological ...
May 2, 2024
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New mRNA cancer vaccine triggers fierce immune response to fight malignant brain tumor
In a first-ever human clinical trial of four adult patients, an mRNA cancer vaccine developed at the University of Florida quickly reprogrammed the immune system to attack glioblastoma, the most aggressive and lethal brain ...
May 1, 2024
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New technique improves T cell-based immunotherapies for solid tumors
Scientists from Scripps Research have enhanced an existing immunotherapy by removing the sugar coating surrounding solid tumors—such as in melanoma, breast, and prostate cancer—so T cells can more effectively kill tumor ...
May 1, 2024
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Experimental vaccine targets portions of the flu virus that don't change
Duke researchers have opened a new avenue in the attack against influenza viruses by creating a vaccine that encourages the immune system to target a portion of the virus surface that is less variable.
May 1, 2024
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Scientists identify new brain circuit in mice that controls body's inflammatory reactions
The brain can direct the immune system to an unexpected degree, capable of detecting, ramping up and tamping down inflammation, shows a new study in mice from researchers at Columbia's Zuckerman Institute.
May 1, 2024
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Patients with rheumatoid arthritis have unique and complex autoantibody patterns, study reveals
Patients with rheumatoid arthritis (RA) all have a unique and diverse set of antibodies that are involved in the development of the disease. Researchers at Utrecht University unveiled the complexity of these antibodies using ...
May 1, 2024
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Researchers find difference in pancreatic cancer cells, offering new hope for immunotherapy effectiveness
A new study has found that pancreatic cancer cells are different based on their location in the pancreas, providing new information about tumors that could lead to better targeted treatments.
May 1, 2024
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